Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease

Preclinical efficacy of continuous delivery of 3,4-dihydroxyphenylalanine (DOPA) with adeno-associated viral (AAV) vectors has recently been documented in animal models of Parkinson's disease (PD). So far, all studies have utilized a mix of two monocistronic vectors expressing either of the two...

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Hlavní autoři: Cederfjäll, Erik, Sahin, Gurdal, Kirik, Deniz, Björklund, Tomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392974/
https://ncbi.nlm.nih.gov/pubmed/22294150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.1
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