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Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA–induced dyskinesia in rats

Drug-induced dyskinesias in dopamine-denervated animals are known to depend on both pre- and postsynaptic changes of the nigrostriatal circuitry. In lesion models used thus far, changes occur in both of these compartments and, therefore, it has not been possible to dissect the individual contributio...

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Autores principales: Ulusoy, Ayse, Sahin, Gurdal, Kirik, Deniz
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919904/
https://ncbi.nlm.nih.gov/pubmed/20615977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1003432107
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