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Presynaptic effects of L-DOPA and their possible role in dyskinesia

L-DOPA replacement therapy has long provided the most effective treatment for Parkinson’s disease. We review how this dopamine precursor enhances dopaminergic transmission by providing a greater sphere of neurotransmitter influence, due to the confluence of increased quantal size and decreased dopam...

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Bibliografiske detaljer
Udgivet i:Mov Disord
Main Authors: Mosharov, Eugene V., Borgkvist, Anders, Sulzer, David
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314471/
https://ncbi.nlm.nih.gov/pubmed/25450307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.26103
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