Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease

Por Cederfjäll, Erik, Sahin, Gurdal, Kirik, Deniz, Björklund, Tomas
Publicado em 2012

Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons

Por Ulusoy, Ayse, Sahin, Gurdal, Björklund, Tomas, Aebischer, Patrick, Kirik, Deniz
Publicado em 2009

Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson’s disease

Por Björklund, Tomas, Carlsson, Thomas, Cederfjäll, Erik Ahlm, Carta, Manolo, Kirik, Deniz
Publicado em 2010

A general chemical method to regulate protein stability in the mammalian central nervous system

Por Iwamoto, Mari, Björklund, Tomas, Lundberg, Cecilia, Kirik, Deniz, Wandless, Thomas J.
Publicado em 2010

Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons

Por Aldrin-Kirk, Patrick, Davidsson, Marcus, Holmqvist, Staffan, Li, Jia-Yi, Björklund, Tomas
Publicado em 2014

A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing

Por Davidsson, Marcus, Diaz-Fernandez, Paula, Schwich, Oliver D., Torroba, Marcos, Wang, Gang, Björklund, Tomas
Publicado no Sci Rep (2016)

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor

Por Aldrin-Kirk, Patrick, Heuer, Andreas, Wang, Gang, Mattsson, Bengt, Lundblad, Martin, Parmar, Malin, Björklund, Tomas
Publicado no Neuron (2016)

Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

Por Dodiya, Hemraj B, Bjorklund, Tomas, Stansell III, James, Mandel, Ronald J, Kirik, Deniz, Kordower, Jeffrey H
Publicado em 2009

Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease

Por Cederfjäll, Erik, Nilsson, Nathalie, Sahin, Gurdal, Chu, Yaping, Nikitidou, Elisabeth, Björklund, Tomas, Kordower, Jeffrey H., Kirik, Deniz
Publicado em 2013

Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson’s Disease

Por Kurowska, Zuzanna, Jewett, Michael, Brattås, Per Ludvik, Jimenez-Ferrer, Itzia, Kenéz, Xuyian, Björklund, Tomas, Nordström, Ulrika, Brundin, Patrik, Swanberg, Maria
Publicado no Sci Rep (2016)