Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease

We used a single adeno-associated viral (AAV) vector co-expressing tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) to investigate the relationship between vector dose, and the magnitude and rate of recovery in hemi-parkinsonian rats. Intrastriatal injections of >1E10 genomic copies (gc)...

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Huvudupphovsmän: Cederfjäll, Erik, Nilsson, Nathalie, Sahin, Gurdal, Chu, Yaping, Nikitidou, Elisabeth, Björklund, Tomas, Kordower, Jeffrey H., Kirik, Deniz
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703607/
https://ncbi.nlm.nih.gov/pubmed/23831692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02157
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