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Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease
Conventional symptomatic treatment for Parkinson's disease (PD) with long-term L-3,4-dihydroxyphenylalanine (DOPA) is complicated with development of drug-induced side effects. In vivo viral vector-mediated gene expression encoding tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) provi...
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| 發表在: | Mol Ther |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424040/ https://ncbi.nlm.nih.gov/pubmed/25592335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.8 |
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