Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease

Conventional symptomatic treatment for Parkinson's disease (PD) with long-term L-3,4-dihydroxyphenylalanine (DOPA) is complicated with development of drug-induced side effects. In vivo viral vector-mediated gene expression encoding tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) provi...

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Udgivet i:Mol Ther
Main Authors: Cederfjäll, Erik, Broom, Lauren, Kirik, Deniz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424040/
https://ncbi.nlm.nih.gov/pubmed/25592335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.8
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