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Controlled Striatal DOPA Production From a Gene Delivery System in a Rodent Model of Parkinson's Disease
Conventional symptomatic treatment for Parkinson's disease (PD) with long-term L-3,4-dihydroxyphenylalanine (DOPA) is complicated with development of drug-induced side effects. In vivo viral vector-mediated gene expression encoding tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) provi...
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| Publié dans: | Mol Ther |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4424040/ https://ncbi.nlm.nih.gov/pubmed/25592335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.8 |
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