Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons

Short-hairpin RNA (shRNA)–mediated gene knockdown is a powerful tool for targeted gene silencing and an emerging novel therapeutic strategy. Recent publications, however, reported unexpected toxicity after utilizing viral-mediated shRNA knockdown in vivo. Thus, it is currently unclear whether shRNA-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ulusoy, Ayse, Sahin, Gurdal, Björklund, Tomas, Aebischer, Patrick, Kirik, Deniz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835264/
https://ncbi.nlm.nih.gov/pubmed/19584816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.142
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