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Dose Optimization for Long-term rAAV-mediated RNA Interference in the Nigrostriatal Projection Neurons
Short-hairpin RNA (shRNA)–mediated gene knockdown is a powerful tool for targeted gene silencing and an emerging novel therapeutic strategy. Recent publications, however, reported unexpected toxicity after utilizing viral-mediated shRNA knockdown in vivo. Thus, it is currently unclear whether shRNA-...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2835264/ https://ncbi.nlm.nih.gov/pubmed/19584816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.142 |
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