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Inhibitory Tract Traps the Epithelial Na(+) Channel in a Low Activity Conformation
Proteolysis plays an important role in the maturation and activation of epithelial Na(+) channels (ENaCs). Non-cleaved channels are inactive at high extracellular Na(+) concentrations and fully cleaved channels are constitutively active. Cleavage of the α and γ subunits at multiple sites activates t...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3370254/ https://ncbi.nlm.nih.gov/pubmed/22511777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358218 |
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