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Inhibitory Tract Traps the Epithelial Na(+) Channel in a Low Activity Conformation

Proteolysis plays an important role in the maturation and activation of epithelial Na(+) channels (ENaCs). Non-cleaved channels are inactive at high extracellular Na(+) concentrations and fully cleaved channels are constitutively active. Cleavage of the α and γ subunits at multiple sites activates t...

詳細記述

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書誌詳細
主要な著者: Kashlan, Ossama B., Blobner, Brandon M., Zuzek, Zachary, Carattino, Marcelo D., Kleyman, Thomas R.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370254/
https://ncbi.nlm.nih.gov/pubmed/22511777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358218
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