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Na(+) Inhibits the Epithelial Na(+) Channel by Binding to a Site in an Extracellular Acidic Cleft

The epithelial Na(+) channel (ENaC) has a key role in the regulation of extracellular fluid volume and blood pressure. ENaC belongs to a family of ion channels that sense the external environment. These channels have large extracellular regions that are thought to interact with environmental cues, s...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Kashlan, Ossama B., Blobner, Brandon M., Zuzek, Zachary, Tolino, Michael, Kleyman, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281758/
https://ncbi.nlm.nih.gov/pubmed/25389295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.606152
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