Constraint-based, Homology Model of the Extracellular Domain of the Epithelial Na(+) Channel α Subunit Reveals a Mechanism of Channel Activation by Proteases

The epithelial Na(+) channel (ENaC) mediates Na(+) transport across high resistance epithelia. This channel is assembled from three homologous subunits with the majority of the protein's mass found in the extracellular domains. Acid-sensing ion channel 1 (ASIC1) is homologous to ENaC, but a key...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kashlan, Ossama B., Adelman, Joshua L., Okumura, Sora, Blobner, Brandon M., Zuzek, Zachary, Hughey, Rebecca P., Kleyman, Thomas R., Grabe, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Membrane Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3013024/
https://ncbi.nlm.nih.gov/pubmed/20974852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167098
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