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Constraint-based, Homology Model of the Extracellular Domain of the Epithelial Na(+) Channel α Subunit Reveals a Mechanism of Channel Activation by Proteases
The epithelial Na(+) channel (ENaC) mediates Na(+) transport across high resistance epithelia. This channel is assembled from three homologous subunits with the majority of the protein's mass found in the extracellular domains. Acid-sensing ion channel 1 (ASIC1) is homologous to ENaC, but a key...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3013024/ https://ncbi.nlm.nih.gov/pubmed/20974852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167098 |
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