Pore-lining residues of MEC-4 and MEC-10 channel subunits tune the Caenorhabditis elegans degenerin channel's response to shear stress

The Caenorhabditis elegans MEC-4/MEC-10 channel mediates the worm's response to gentle body touch and is activated by laminar shear stress (LSS) when expressed in Xenopus oocytes. Substitutions at multiple sites within the second transmembrane domain (TM2) of MEC-4 or MEC-10 abolish the gentle...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Shi, Shujie, Mutchler, Stephanie M., Blobner, Brandon M., Kashlan, Ossama B., Kleyman, Thomas R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Membrane Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036219/
https://ncbi.nlm.nih.gov/pubmed/29743244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002499
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