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Pore-lining residues of MEC-4 and MEC-10 channel subunits tune the Caenorhabditis elegans degenerin channel's response to shear stress

The Caenorhabditis elegans MEC-4/MEC-10 channel mediates the worm's response to gentle body touch and is activated by laminar shear stress (LSS) when expressed in Xenopus oocytes. Substitutions at multiple sites within the second transmembrane domain (TM2) of MEC-4 or MEC-10 abolish the gentle...

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Pubblicato in:J Biol Chem
Autori principali: Shi, Shujie, Mutchler, Stephanie M., Blobner, Brandon M., Kashlan, Ossama B., Kleyman, Thomas R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036219/
https://ncbi.nlm.nih.gov/pubmed/29743244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002499
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