Allosteric Inhibition of the Epithelial Na(+) Channel through Peptide Binding at Peripheral Finger and Thumb Domains

The epithelial Na(+) channel (ENaC) mediates the rate-limiting step in transepithelial Na(+) transport in the distal segments of the nephron and in the lung. ENaC subunits are cleaved by proteases, resulting in channel activation due to the release of inhibitory tracts. Peptides derived from these t...

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Главные авторы: Kashlan, Ossama B., Boyd, Cary R., Argyropoulos, Christos, Okumura, Sora, Hughey, Rebecca P., Grabe, Michael, Kleyman, Thomas R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Membrane Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966135/
https://ncbi.nlm.nih.gov/pubmed/20817728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167064
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