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Allosteric Inhibition of the Epithelial Na(+) Channel through Peptide Binding at Peripheral Finger and Thumb Domains
The epithelial Na(+) channel (ENaC) mediates the rate-limiting step in transepithelial Na(+) transport in the distal segments of the nephron and in the lung. ENaC subunits are cleaved by proteases, resulting in channel activation due to the release of inhibitory tracts. Peptides derived from these t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966135/ https://ncbi.nlm.nih.gov/pubmed/20817728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167064 |
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