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Base of the Thumb Domain Modulates Epithelial Sodium Channel Gating

The activity of the epithelial sodium channel (ENaC) is modulated by multiple external factors, including proteases, cations, anions and shear stress. The resolved crystal structure of acid-sensing ion channel 1 (ASIC1), a structurally related ion channel, and mutagenesis studies suggest that the la...

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Detalhes bibliográficos
Main Authors: Shi, Shujie, Ghosh, D. Dipon, Okumura, Sora, Carattino, Marcelo D., Kashlan, Ossama B., Sheng, Shaohu, Kleyman, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083234/
https://ncbi.nlm.nih.gov/pubmed/21367859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.191734
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