Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel

Proteases activate the epithelial sodium channel (ENaC) by cleaving the large extracellular domains of the α- and γ-subunits and releasing peptides with inhibitory properties. Furin and prostasin activate mouse ENaC by cleaving the γ-subunit at sites flanking a 43 residue inhibitory tract (γE144-K18...

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Main Authors: Passero, Christopher J., Carattino, Marcelo D., Kashlan, Ossama B., Myerburg, Mike M., Hughey, Rebecca P., Kleyman, Thomas R.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2010
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957262/
https://ncbi.nlm.nih.gov/pubmed/20630937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00316.2010
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