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TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site

The epithelial sodium channel (ENaC) is activated by a unique mechanism, whereby inhibitory tracts are released by proteolytic cleavage within the extracellular loops of two of its three homologous subunits. While cleavage by furin within the biosynthetic pathway releases one inhibitory tract from t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Passero, Christopher J., Mueller, Gunhild M., Myerburg, Michael M., Carattino, Marcelo D., Hughey, Rebecca P., Kleyman, Thomas R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251344/
https://ncbi.nlm.nih.gov/pubmed/21993886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00330.2011
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