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Proteolytic Processing of the Epithelial Sodium Channel γ Subunit Has a Dominant Role in Channel Activation

Maturation of the epithelial sodium channel (ENaC) involves furin-dependent cleavage at two extracellular sites within the α subunit and at a single extracellular site within the γ subunit. Channels lacking furin processing of the α subunit have very low activity. We recently identified a prostasin-...

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Detalhes bibliográficos
Main Authors: Carattino, Marcelo D., Hughey, Rebecca P., Kleyman, Thomas R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533072/
https://ncbi.nlm.nih.gov/pubmed/18650438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803931200
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