TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage site

The epithelial sodium channel (ENaC) is activated by a unique mechanism, whereby inhibitory tracts are released by proteolytic cleavage within the extracellular loops of two of its three homologous subunits. While cleavage by furin within the biosynthetic pathway releases one inhibitory tract from t...

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Main Authors: Passero, Christopher J., Mueller, Gunhild M., Myerburg, Michael M., Carattino, Marcelo D., Hughey, Rebecca P., Kleyman, Thomas R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2012
Ábhair:
Call for Papers
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251344/
https://ncbi.nlm.nih.gov/pubmed/21993886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00330.2011
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