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Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block
The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (P(o)) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits or of all three subunits...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3882368/ https://ncbi.nlm.nih.gov/pubmed/24107424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00337.2013 |
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