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Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block

The epithelial sodium channel (ENaC) is comprised of three homologous subunits. Channels composed solely of α- and β-subunits (αβ-channels) exhibit a very high open probability (P(o)) and reduced sensitivity to amiloride, in contrast to channels composed of α- and γ-subunits or of all three subunits...

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Bibliografiska uppgifter
Huvudupphovsmän: Shi, Shujie, Kleyman, Thomas R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2013
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882368/
https://ncbi.nlm.nih.gov/pubmed/24107424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00337.2013
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