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Defining an inhibitory domain in the gamma subunit of the epithelial sodium channel
Proteases activate the epithelial sodium channel (ENaC) by cleaving the large extracellular domains of the α- and γ-subunits and releasing peptides with inhibitory properties. Furin and prostasin activate mouse ENaC by cleaving the γ-subunit at sites flanking a 43 residue inhibitory tract (γE144-K18...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Physiological Society
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957262/ https://ncbi.nlm.nih.gov/pubmed/20630937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00316.2010 |
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