The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD mutations increase the release of amyloid β (Aβ)42 relative to Aβ40 by an unknown, possibly gain-of-toxic-function, mechanism. Howeve...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Chávez-Gutiérrez, Lucía, Bammens, Leen, Benilova, Iryna, Vandersteen, Annelies, Benurwar, Manasi, Borgers, Marianne, Lismont, Sam, Zhou, Lujia, Van Cleynenbreugel, Simon, Esselmann, Hermann, Wiltfang, Jens, Serneels, Lutgarde, Karran, Eric, Gijsen, Harrie, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa, De Strooper, Bart
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2012
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364747/
https://ncbi.nlm.nih.gov/pubmed/22505025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.79
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים