Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation†

BACE1 cleaves the amyloid precursor protein (APP) at the β-cleavage site (Met(671)–Asp(672)) to initiate the generation of amyloid peptide Aβ. BACE1 is also known to cleave APP at a much less well-characterized β′-cleavage site (Tyr(681)–Glu(682)). We describe here the identification of a novel APP...

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Detalhes bibliográficos
Main Authors: Zhou, Lujia, Brouwers, Nathalie, Benilova, Iryna, Vandersteen, Annelies, Mercken, Marc, Van Laere, Koen, Van Damme, Philip, Demedts, David, Van Leuven, Fred, Sleegers, Kristel, Broersen, Kerensa, Van Broeckhoven, Christine, Vandenberghe, Rik, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377078/
https://ncbi.nlm.nih.gov/pubmed/21500352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100138
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