Molecular Plasticity Regulates Oligomerization and Cytotoxicity of the Multipeptide-length Amyloid-β Peptide Pool

Current therapeutic approaches under development for Alzheimer disease, including γ-secretase modulating therapy, aim at increasing the production of Aβ(1–38) and Aβ(1–40) at the cost of longer Aβ peptides. Here, we consider the aggregation of Aβ(1–38) and Aβ(1–43) in addition to Aβ(1–40) and Aβ(1–4...

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Autori principali: Vandersteen, Annelies, Masman, Marcelo F., De Baets, Greet, Jonckheere, Wim, van der Werf, Kees, Marrink, Siewert J., Rozenski, Jef, Benilova, Iryna, De Strooper, Bart, Subramaniam, Vinod, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481277/
https://ncbi.nlm.nih.gov/pubmed/22992745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394635
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