Molecular Plasticity Regulates Oligomerization and Cytotoxicity of the Multipeptide-length Amyloid-β Peptide Pool

Current therapeutic approaches under development for Alzheimer disease, including γ-secretase modulating therapy, aim at increasing the production of Aβ(1–38) and Aβ(1–40) at the cost of longer Aβ peptides. Here, we consider the aggregation of Aβ(1–38) and Aβ(1–43) in addition to Aβ(1–40) and Aβ(1–4...

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Detalhes bibliográficos
Main Authors: Vandersteen, Annelies, Masman, Marcelo F., De Baets, Greet, Jonckheere, Wim, van der Werf, Kees, Marrink, Siewert J., Rozenski, Jef, Benilova, Iryna, De Strooper, Bart, Subramaniam, Vinod, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481277/
https://ncbi.nlm.nih.gov/pubmed/22992745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394635
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