Molecular Plasticity Regulates Oligomerization and Cytotoxicity of the Multipeptide-length Amyloid-β Peptide Pool

Current therapeutic approaches under development for Alzheimer disease, including γ-secretase modulating therapy, aim at increasing the production of Aβ(1–38) and Aβ(1–40) at the cost of longer Aβ peptides. Here, we consider the aggregation of Aβ(1–38) and Aβ(1–43) in addition to Aβ(1–40) and Aβ(1–4...

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Hlavní autoři: Vandersteen, Annelies, Masman, Marcelo F., De Baets, Greet, Jonckheere, Wim, van der Werf, Kees, Marrink, Siewert J., Rozenski, Jef, Benilova, Iryna, De Strooper, Bart, Subramaniam, Vinod, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481277/
https://ncbi.nlm.nih.gov/pubmed/22992745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394635
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