Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ(42) to Aβ(40) ratio

The amyloid peptides Aβ(40) and Aβ(42) of Alzheimer's disease are thought to contribute differentially to the disease process. Although Aβ(42) seems more pathogenic than Aβ(40), the reason for this is not well understood. We show here that small alterations in the Aβ(42):Aβ(40) ratio dramatical...

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Detalhes bibliográficos
Main Authors: Kuperstein, Inna, Broersen, Kerensa, Benilova, Iryna, Rozenski, Jef, Jonckheere, Wim, Debulpaep, Maja, Vandersteen, Annelies, Segers-Nolten, Ine, Van Der Werf, Kees, Subramaniam, Vinod, Braeken, Dries, Callewaert, Geert, Bartic, Carmen, D'Hooge, Rudi, Martins, Ivo Cristiano, Rousseau, Frederic, Schymkowitz, Joost, De Strooper, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957213/
https://ncbi.nlm.nih.gov/pubmed/20818335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.211
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