The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD mutations increase the release of amyloid β (Aβ)42 relative to Aβ40 by an unknown, possibly gain-of-toxic-function, mechanism. Howeve...

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Hauptverfasser: Chávez-Gutiérrez, Lucía, Bammens, Leen, Benilova, Iryna, Vandersteen, Annelies, Benurwar, Manasi, Borgers, Marianne, Lismont, Sam, Zhou, Lujia, Van Cleynenbreugel, Simon, Esselmann, Hermann, Wiltfang, Jens, Serneels, Lutgarde, Karran, Eric, Gijsen, Harrie, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa, De Strooper, Bart
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3364747/
https://ncbi.nlm.nih.gov/pubmed/22505025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.79
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