Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect in the proteolytic clearance of autophagy substrates. Autophagy failure contributes on several levels to AD pathogenesis and has become an important therapeutic target for AD and other neurodegen...

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Detalhes bibliográficos
Main Authors: Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S, Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D, Wesson, Daniel W, Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M, Yang, Austin J, Wilson, Donald A, St George-Hyslop, Peter, Westaway, David, Mathews, Paul M, Levy, Efrat, Cuervo, Ana M, Nixon, Ralph A
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Autophagic Punctum
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359468/
https://ncbi.nlm.nih.gov/pubmed/21464620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.7.15596
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