Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect in the proteolytic clearance of autophagy substrates. Autophagy failure contributes on several levels to AD pathogenesis and has become an important therapeutic target for AD and other neurodegen...

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Detalles Bibliográficos
Autores principales: Yang, Dun-Sheng, Stavrides, Philip, Mohan, Panaiyur S, Kaushik, Susmita, Kumar, Asok, Ohno, Masuo, Schmidt, Stephen D, Wesson, Daniel W, Bandyopadhyay, Urmi, Jiang, Ying, Pawlik, Monika, Peterhoff, Corrinne M, Yang, Austin J, Wilson, Donald A, St George-Hyslop, Peter, Westaway, David, Mathews, Paul M, Levy, Efrat, Cuervo, Ana M, Nixon, Ralph A
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2011
Materias:
Autophagic Punctum
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359468/
https://ncbi.nlm.nih.gov/pubmed/21464620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.7.15596
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