Breast and Ovarian Cancer Risk and Risk Reduction in Jewish BRCA1/2 Mutation Carriers

PURPOSE: Mutations in BRCA1/2 dramatically increase the risk of both breast and ovarian cancers. Three mutations in these genes (185delAG, 5382insC, and 6174delT) occur at high frequency in Ashkenazi Jews. We evaluated how these common Jewish mutations (CJMs) affect cancer risks and risk reduction....

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Autors principals: Finkelman, Brian S., Rubinstein, Wendy S., Friedman, Sue, Friebel, Tara M., Dubitsky, Shera, Schonberger, Niecee Singer, Shoretz, Rochelle, Singer, Christian F., Blum, Joanne L., Tung, Nadine, Olopade, Olufunmilayo I., Weitzel, Jeffrey N., Lynch, Henry T., Snyder, Carrie, Garber, Judy E., Schildkraut, Joellen, Daly, Mary B., Isaacs, Claudine, Pichert, Gabrielle, Neuhausen, Susan L., Couch, Fergus J., van't Veer, Laura, Eeles, Rosalind, Bancroft, Elizabeth, Evans, D. Gareth, Ganz, Patricia A., Tomlinson, Gail E., Narod, Steven A., Matloff, Ellen, Domchek, Susan, Rebbeck, Timothy R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Clinical Oncology 2012
Matèries:
Original Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341145/
https://ncbi.nlm.nih.gov/pubmed/22430266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.37.8133
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