Breast and Ovarian Cancer Risk and Risk Reduction in Jewish BRCA1/2 Mutation Carriers

PURPOSE: Mutations in BRCA1/2 dramatically increase the risk of both breast and ovarian cancers. Three mutations in these genes (185delAG, 5382insC, and 6174delT) occur at high frequency in Ashkenazi Jews. We evaluated how these common Jewish mutations (CJMs) affect cancer risks and risk reduction....

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Bibliografische gegevens
Hoofdauteurs: Finkelman, Brian S., Rubinstein, Wendy S., Friedman, Sue, Friebel, Tara M., Dubitsky, Shera, Schonberger, Niecee Singer, Shoretz, Rochelle, Singer, Christian F., Blum, Joanne L., Tung, Nadine, Olopade, Olufunmilayo I., Weitzel, Jeffrey N., Lynch, Henry T., Snyder, Carrie, Garber, Judy E., Schildkraut, Joellen, Daly, Mary B., Isaacs, Claudine, Pichert, Gabrielle, Neuhausen, Susan L., Couch, Fergus J., van't Veer, Laura, Eeles, Rosalind, Bancroft, Elizabeth, Evans, D. Gareth, Ganz, Patricia A., Tomlinson, Gail E., Narod, Steven A., Matloff, Ellen, Domchek, Susan, Rebbeck, Timothy R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Clinical Oncology 2012
Onderwerpen:
Original Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341145/
https://ncbi.nlm.nih.gov/pubmed/22430266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.37.8133
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