Breast and Ovarian Cancer Risk and Risk Reduction in Jewish BRCA1/2 Mutation Carriers

PURPOSE: Mutations in BRCA1/2 dramatically increase the risk of both breast and ovarian cancers. Three mutations in these genes (185delAG, 5382insC, and 6174delT) occur at high frequency in Ashkenazi Jews. We evaluated how these common Jewish mutations (CJMs) affect cancer risks and risk reduction....

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Autores principales: Finkelman, Brian S., Rubinstein, Wendy S., Friedman, Sue, Friebel, Tara M., Dubitsky, Shera, Schonberger, Niecee Singer, Shoretz, Rochelle, Singer, Christian F., Blum, Joanne L., Tung, Nadine, Olopade, Olufunmilayo I., Weitzel, Jeffrey N., Lynch, Henry T., Snyder, Carrie, Garber, Judy E., Schildkraut, Joellen, Daly, Mary B., Isaacs, Claudine, Pichert, Gabrielle, Neuhausen, Susan L., Couch, Fergus J., van't Veer, Laura, Eeles, Rosalind, Bancroft, Elizabeth, Evans, D. Gareth, Ganz, Patricia A., Tomlinson, Gail E., Narod, Steven A., Matloff, Ellen, Domchek, Susan, Rebbeck, Timothy R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Clinical Oncology 2012
Materias:
Original Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341145/
https://ncbi.nlm.nih.gov/pubmed/22430266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.37.8133
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