Genetic Variation in IGF2 and HTRA1 and Breast Cancer Risk among BRCA1 and BRCA2 Carriers

BACKGROUND: BRCA1 and BRCA2 mutation carriers have a lifetime breast cancer risk of 40% to 80%, suggesting the presence of risk modifiers. We previously identified significant associations in genetic variants in the insulin-like growth factor (IGF) signaling pathway. Here, we investigate additional...

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Autors principals: Neuhausen, Susan L., Brummel, Sean, Ding, Yuan Chun, Steele, Linda, Nathanson, Katherine L., Domchek, Susan, Rebbeck, Timothy R., Singer, Christian F., Pfeiler, Georg, Lynch, Henry T., Garber, Judy E., Couch, Fergus, Weitzel, Jeffrey N., Godwin, Andrew, Narod, Steven A., Ganz, Patricia A., Daly, Mary B., Isaacs, Claudine, Olopade, Olufunmilayo I., Tomlinson, Gail E., Rubinstein, Wendy S., Tung, Nadine, Blum, Joanne L., Gillen, Daniel L.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352680/
https://ncbi.nlm.nih.gov/pubmed/21708937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-10-1336
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