Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers with Cancer Risk and Mortality

CONTEXT: Risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO) are widely used by carriers of BRCA1 or BRCA2 mutations to reduce their risks of breast and ovarian cancer. OBJECTIVES: To estimate risk and mortality reduction stratified by mutation and prior cancer status. DESIGN: A prospect...

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Main Authors: Domchek, Susan M., Friebel, Tara M., Singer, Christian F., Evans, D. Gareth, Lynch, Henry T., Isaacs, Claudine, Garber, Judy E., Neuhausen, Susan L., Matloff, Ellen, Eeles, Rosalind, Pichert, Gabriella, Van t'veer, Laura, Tung, Nadine, Weitzel, Jeffrey N., Couch, Fergus J., Rubinstein, Wendy S., Ganz, Patricia A., Daly, Mary B., Olopade, Olufunmilayo I., Tomlinson, Gail, Schildkraut, Joellen, Blum, Joanne L., Rebbeck, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2948529/
https://ncbi.nlm.nih.gov/pubmed/20810374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2010.1237
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