Breast and Ovarian Cancer Risk and Risk Reduction in Jewish BRCA1/2 Mutation Carriers

PURPOSE: Mutations in BRCA1/2 dramatically increase the risk of both breast and ovarian cancers. Three mutations in these genes (185delAG, 5382insC, and 6174delT) occur at high frequency in Ashkenazi Jews. We evaluated how these common Jewish mutations (CJMs) affect cancer risks and risk reduction....

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Detalhes bibliográficos
Main Authors: Finkelman, Brian S., Rubinstein, Wendy S., Friedman, Sue, Friebel, Tara M., Dubitsky, Shera, Schonberger, Niecee Singer, Shoretz, Rochelle, Singer, Christian F., Blum, Joanne L., Tung, Nadine, Olopade, Olufunmilayo I., Weitzel, Jeffrey N., Lynch, Henry T., Snyder, Carrie, Garber, Judy E., Schildkraut, Joellen, Daly, Mary B., Isaacs, Claudine, Pichert, Gabrielle, Neuhausen, Susan L., Couch, Fergus J., van't Veer, Laura, Eeles, Rosalind, Bancroft, Elizabeth, Evans, D. Gareth, Ganz, Patricia A., Tomlinson, Gail E., Narod, Steven A., Matloff, Ellen, Domchek, Susan, Rebbeck, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2012
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341145/
https://ncbi.nlm.nih.gov/pubmed/22430266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2011.37.8133
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