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Modifiers of Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: Systematic Review and Meta-Analysis

BACKGROUND: There is substantial variability in cancer risk in women who have inherited a BRCA1 or BRCA2 (BRCA1/2) mutation. Numerous factors have been hypothesized to modify these risks, but studies are of variable quality, and it remains unclear which of these may be of value in clinical risk asse...

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Hlavní autoři: Friebel, Tara M., Domchek, Susan M., Rebbeck, Timothy R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081625/
https://ncbi.nlm.nih.gov/pubmed/24824314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/dju091
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