Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

INTRODUCTION: Women who carry mutations in BRCA1 and BRCA2 have a substantially increased risk of developing breast cancer as compared with the general population. However, risk estimates range from 20 to 80%, suggesting the presence of genetic and/or environmental risk modifiers. Based on extensive...

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Main Authors: Neuhausen, Susan L, Brummel, Sean, Ding, Yuan Chun, Singer, Christian F, Pfeiler, Georg, Lynch, Henry T, Nathanson, Katherine L, Rebbeck, Timothy R, Garber, Judy E, Couch, Fergus, Weitzel, Jeffrey, Narod, Steven A, Ganz, Patricia A, Daly, Mary B, Godwin, Andrew K, Isaacs, Claudine, Olopade, Olufunmilayo I, Tomlinson, Gail, Rubinstein, Wendy S, Tung, Nadine, Blum, Joanne L, Gillen, Daniel L
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790858/
https://ncbi.nlm.nih.gov/pubmed/19843326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2414
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