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Suppression of Cytokine Signalling by SOCS3: Characterisation of the mode of inhibition and the basis of its specificity
Janus kinases (JAKs) are key effectors in controlling immune responses and maintaining hematopoiesis. SOCS3 (Suppressor of Cytokine Signaling-3) is a major regulator of JAK signaling and here we investigate the molecular basis of its mechanism of action. We found that SOCS3 bound and directly inhibi...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3299805/ https://ncbi.nlm.nih.gov/pubmed/22342841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.12.015 |
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