Suppression of Cytokine Signalling by SOCS3: Characterisation of the mode of inhibition and the basis of its specificity

Janus kinases (JAKs) are key effectors in controlling immune responses and maintaining hematopoiesis. SOCS3 (Suppressor of Cytokine Signaling-3) is a major regulator of JAK signaling and here we investigate the molecular basis of its mechanism of action. We found that SOCS3 bound and directly inhibi...

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Autori principali: Babon, Jeffrey J., Kershaw, Nadia J., Murphy, James M., Varghese, Leila N., Laktyushin, Artem, Young, Samuel N., Lucet, Isabelle S., Norton, Raymond S., Nicola, Nicos A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299805/
https://ncbi.nlm.nih.gov/pubmed/22342841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.12.015
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