Wird geladen...
Suppression of Cytokine Signalling by SOCS3: Characterisation of the mode of inhibition and the basis of its specificity
Janus kinases (JAKs) are key effectors in controlling immune responses and maintaining hematopoiesis. SOCS3 (Suppressor of Cytokine Signaling-3) is a major regulator of JAK signaling and here we investigate the molecular basis of its mechanism of action. We found that SOCS3 bound and directly inhibi...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3299805/ https://ncbi.nlm.nih.gov/pubmed/22342841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.12.015 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|