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Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: Identification of the active components and JAK2 and gp130 as substrates

SOCS3 (Suppressor of Cytokine Signaling 3) inhibits the intracellular signaling cascade initiated by exposure of cells to cytokines. SOCS3 regulates signaling via two distinct mechanisms: directly inhibiting the catalytic activity of Janus Kinases (JAKs) that initiate the intracellular signaling cas...

詳細記述

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書誌詳細
主要な著者: Kershaw, Nadia J., Laktyushin, Artem, Nicola, Nicos A., Babon, Jeffrey J.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085236/
https://ncbi.nlm.nih.gov/pubmed/24438103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/08977194.2013.877005
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