SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

The inhibitory protein SOCS3 plays a key role in the immune and hematopoietic systems by regulating signaling induced by specific cytokines. SOCS3 functions by inhibiting the catalytic activity of Janus Kinases (JAKs) that initiate signaling within the cell. We determined the crystal structure of a...

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Detaylı Bibliyografya
Asıl Yazarlar: Kershaw, Nadia J., Murphy, James M., Liau, Nicholas P.D., Varghese, Leila N., Laktyushin, Artem, Whitlock, Eden L., Lucet, Isabelle S., Nicola, Nicos A., Babon, Jeffrey J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618588/
https://ncbi.nlm.nih.gov/pubmed/23454976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2519
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