Wnt/β-catenin signaling and AXIN1 regulate apoptosis mediated by inhibition of BRAF(V600E) kinase in human melanoma

As the Wnt/β-catenin signaling pathway is linked to melanoma pathogenesis and to patient survival, we conducted a kinome siRNA screen in melanoma cells to expand our understanding of kinases that regulate this pathway, and to illuminate potential therapeutic directions. We found that BRAF signaling,...

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Autori principali: Biechele, Travis L., Kulikauskas, Rima M., Toroni, Rachel A., Lucero, Olivia M., Swift, Reyna D., James, Richard G., Robin, Nick C., Dawson, David W., Moon, Randall T., Chien, Andy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297477/
https://ncbi.nlm.nih.gov/pubmed/22234612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002274
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