Regulating the response to targeted MEK inhibition in melanoma: Enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation

The limitations of revolutionary new mutation-specific inhibitors of BRAF(V600E) include the universal recurrence seen in melanoma patients treated with this novel class of drugs. Recently, our lab showed that simultaneous activation of the Wnt/β-catenin signaling pathway and targeted inhibition of...

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Huvudupphovsmän: Conrad, William H., Swift, Reyna D., Biechele, Travis L., Kulikauskas, Rima M., Moon, Randall T., Chien, Andy J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2012
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495814/
https://ncbi.nlm.nih.gov/pubmed/22895053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21645
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