Targeted BRAF Inhibition Impacts Survival in Melanoma Patients with High Levels of Wnt/β-Catenin Signaling

Unprecedented clinical responses have been reported in advanced stage metastatic melanoma patients treated with targeted inhibitors of constitutively activated mutant BRAF, which is present in approximately half of all melanomas. We and others have previously observed an association of elevated nucl...

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Main Authors: Chien, Andy J., Haydu, Lauren E., Biechele, Travis L., Kulikauskas, Rima M., Rizos, Helen, Kefford, Richard F., Scolyer, Richard A., Moon, Randall T., Long, Georgina V.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986217/
https://ncbi.nlm.nih.gov/pubmed/24733413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094748
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