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WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
About half of all melanomas harbor a mutation that results in a constitutively active BRAF kinase mutant (BRAF(V600E/K)) that can be selectively inhibited by targeted BRAF inhibitors (BRAFis). While patients treated with BRAFis initially exhibit measurable clinical improvement, the majority of patie...
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| Main Authors: | , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Society for Clinical Investigation
2014
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4071371/ https://ncbi.nlm.nih.gov/pubmed/24865425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70156 |
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