Wnt/β-catenin signaling and AXIN1 regulate apoptosis mediated by inhibition of BRAF(V600E) kinase in human melanoma

As the Wnt/β-catenin signaling pathway is linked to melanoma pathogenesis and to patient survival, we conducted a kinome siRNA screen in melanoma cells to expand our understanding of kinases that regulate this pathway, and to illuminate potential therapeutic directions. We found that BRAF signaling,...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Biechele, Travis L., Kulikauskas, Rima M., Toroni, Rachel A., Lucero, Olivia M., Swift, Reyna D., James, Richard G., Robin, Nick C., Dawson, David W., Moon, Randall T., Chien, Andy J.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3297477/
https://ncbi.nlm.nih.gov/pubmed/22234612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002274
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars