WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors

About half of all melanomas harbor a mutation that results in a constitutively active BRAF kinase mutant (BRAF(V600E/K)) that can be selectively inhibited by targeted BRAF inhibitors (BRAFis). While patients treated with BRAFis initially exhibit measurable clinical improvement, the majority of patie...

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Main Authors: Anastas, Jamie N., Kulikauskas, Rima M., Tamir, Tigist, Rizos, Helen, Long, Georgina V., von Euw, Erika M., Yang, Pei-Tzu, Chen, Hsiao-Wang, Haydu, Lauren, Toroni, Rachel A., Lucero, Olivia M., Chien, Andy J., Moon, Randall T.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2014
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4071371/
https://ncbi.nlm.nih.gov/pubmed/24865425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70156
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