PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis

Despite the role of aerobic glycolysis in cancer, recent studies highlight the importance of the mitochondria and biosynthetic pathways as well. PPARγ coactivator 1α (PGC1α) is a key transcriptional regulator of several metabolic pathways including oxidative metabolism and lipogenesis. Initial studi...

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Hlavní autoři: Bhalla, Kavita, Hwang, Bor Jang, Dewi, Ruby E., Ou, Lihui, Twaddel, William, Fang, Hong-bin, Vafai, Scott B., Vazquez, Francesca, Puigserver, Pere, Boros, Laszlo, Girnun, Geoffrey
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282487/
https://ncbi.nlm.nih.gov/pubmed/21914785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1011
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